Amino acid sequence of the crustacean hyperglycemic hormone (CHH) from the shore crab, <i>Carcinus maenas</i>

Abstract

Crustacean hyperglycemic hormone (CHH) was isolated from sinus glands of Carcinus maenas, and its primary structure was determined by manual microsequencing, using the DABITC-PITC double-coupling method. The neurohormone consists of 72 amino acid residues (8524 Da). Three disulfide bridges are present and both the N- and C-terminus are blocked. CHH does not show significant sequence homology to any known peptide hormone or protein.