Biomacromolecules · 2004 · 269 citations · 20 references
PharmacyMolecular PharmaceuticsPharmaceuticsDrug DeliveryNanoparticle Drug DeliveryOral Drug DeliveryDrug EncapsulationNanomaterials For Drug DeliveryNanomedicineNanoparticle CharacterizationNanoparticle FormulationsOral NanocarriersBovine Serum AlbuminChitosanChitosan NanocarriersGelationGelation MechanismsNanoparticlesParticle-size DistributionPolymer Molecular Weight Distribution
Chitosan nanoparticles (CS NPs) of a controlled size (below 100 nm) and narrow size distribution were obtained through the process of ionic gelation between CS and sodium tripolyphosphate (TPP). A high degree of CS deacetylation and narrow polymer molecular weight distribution were demonstrated to be critical for the controlling particle size distribution. Properties of the CS NPs were examined at different temperatures, values of pH, and ratios of CS to TPP. The model protein, bovine serum albumin, was encapsulated into the NPs, and the in vitro release profiles were examined in physiologically relevant media at 37 degrees C.
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Design of biodegradable particles for protein delivery
Ana Vila, Alejandro Sánchez, Pilar Calvo et al. · Journal of Controlled Release · 2002 · 613 citations