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Asymmetric reduction of prochiral 3-aryl-3-oxoesters with lithium borohydride using N,N′-dibenzoylcystine as a chiral auxiliary
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1985
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Asymmetric CatalysisChemical EngineeringEngineeringLithium BorohydrideProchiral 3-Aryl-3-oxoestersChiral AuxiliaryOrganic ChemistryActive 3-Aryl-3-hydroxyestersStereoselective SynthesisChemistryPharmacologyT-butyl AlcoholSynthetic ChemistryEnantioselective Synthesis
Optically active 3-aryl-3-hydroxyesters of high enantiomeric excess (80–92% e.e.) are obtained by the reduction of 3-aryl-3-oxoesters with lithium borohydride which has been chirally modified with N,N′-dibenzoylcystine and t-butyl alcohol.