Concepedia

Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis

Jennifer D. Hamilton, Mayte Suárez‐Fariñas, Nikhil Dhingra, Irma Cardinale, Xuan Li, Ana Kostić, Jeffrey E. Ming, Allen Radin, James G. Krueger, Neil M.H. Graham,

Journal of Allergy and Clinical Immunology · 2014 · 460 citations · 27 references

DOIFull text

Open access

Abstract

This is the first report showing rapid improvement of the AD molecular signature with targeted anti-IL-4 receptor α therapy. These data suggest that IL-4 and IL-13 drive a complex, TH2-centered inflammatory axis in patients with AD.

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