Concepedia

L-Carnitine Attenuates the Development of Kidney Fibrosis in Hypertensive Rats by Upregulating PPAR- 

Sonia Zambrano, A. J. Blanca, María V. Ruiz‐Armenta, José L. Miguel‐Carrasco, M. Arevalo, Alfonso Mate, Carmen M. Vázquez

American Journal of Hypertension · 2014 · 55 citations · 29 references

DOIFull text

Open access

Abstract

This study confirms the efficacy of L-carnitine against hypertension-associated renal fibrosis from in vivo and in vitro studies and suggests that the L-carnitine effect occurs in a PPAR-γ-dependent manner.

References

29

Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor–β–Dependent and –Independent Smad Pathways

Fuye Yang, Arthur C.K. Chung, Xiao Ru Huang et al. · Hypertension · 2009 · 258 citations

PPARα Activator Effects on Ang II–Induced Vascular Oxidative Stress and Inflammation

Quy N. Diep, Farhad Amiri, Rhian M. Touyz et al. · Hypertension · 2002 · 233 citations

, , +14

PPAR-γ agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-β

Tōru Kawai, Takao Masaki, Shigehiro Doi et al. · Laboratory Investigation · 2008 · 198 citations · Full text

, , +17

Effect of l-carnitine on the status of lipid peroxidation and antioxidants in aging rats

Thangavel Kalaiselvi, Chinnakkannu Panneerselvam · The Journal of Nutritional Biochemistry · 1998 · 144 citations

, , +6

L-Carnitine Ameliorates Oxidative Damage due to Chronic Renal Failure in Rats

Göksel Şener, Kübra Paskaloǧlu, Handan Şatıroğlu et al. · Journal of Cardiovascular Pharmacology · 2004 · 117 citations

, , +14