Concepedia

Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2′-oxindole] Derivatives

Xianjie Chen, Hui Chen, Xun Ji, Hualiang Jiang, Zhu‐Jun Yao, Hong Liu

Organic Letters · 2013 · 115 citations · 42 references

DOI

Concepts

Abstract

An asymmetric organo- and gold-catalyzed one-pot sequential Mannich/hydroamination reaction has been developed. Using this protocol, spiro[pyrrolidin-3,2'-oxindole] derivatives were synthesized in good yields (up to 91%) and excellent enantioselectivities (up to 97% ee).

References

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