Synthesis of Pyrroles via Ethyl<i>N</i>-(3-Oxo-1-alkenyl)glycinates

Abstract

The reaction of ethyl glycinate hydrochloride (1) with 1,3-dicarbonyl compounds 2a-g in presence of triethylamine leads to the formation of ethyl N-(3-oxo-1-alkenyl)glycinates 3a-g. These compounds are easily converted to the pyrroles 4a-g by base-catalyzed intramolecular Knoevenagel condensation.