Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α - Concepedia

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Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α

DOI Full Paper Access

37

Citations

37

References

2015

Year

Marijke J. E. Kuijpers, Nadine J.A. Mattheij, Lina Cipolla, Johanna P. van Geffen, Toby Lawrence, Marjo M. P. C. Donners, Louis Boon, Dirk Lievens, Mauro Torti, Heidi Noels,

Arteriosclerosis Thrombosis and Vascular Biology

Abstract

Under atherogenic conditions, CD40L enhances collagen-induced platelet-platelet interactions by supporting integrin αIIbβ3 activation, secretion and thrombus growth via PI3Kβ, but not via CD40 and IKKα/NFκB. This role of CD40L exceeds the no more than modest role of CD40 in thrombus formation.

References

	Year	Citations

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