IL-10-deficiency unmasks unique immune system defects and reveals differential regulation of organ-specific autoimmunity in non-obese diabetic mice

A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature · 2000 · 6.4K citations

Life Sciences, Immunology, Microbiology +13

Interleukin-10-deficient mice develop chronic enterocolitis

Ralf Kühn, Jürgen Löhler, D Rennick et al. · Cell · 1993 · 4.3K citations

Veterinary Medicine, Immunology, Infectious Diseases +14

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Rance K. Sellon, Susan L. Tonkonogy, Michael Schultz et al. · Infection and Immunity · 1998 · 1.5K citations · Full text

Life Sciences, Immunology, Microbiology +17

Multiple defects in innate and adaptive immunologic function in NOD/LtSz- <i>scid</i> mice.

Leonard D. Shultz, Peter A. Schweitzer, Sherri W. Christianson et al. · The Journal of Immunology · 1995 · 1.2K citations

Life Sciences, Immunology, Pathology +11

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α

Ricardo T. Gazzinelli, Maria Wysocka, Sara Hieny et al. · The Journal of Immunology · 1996 · 929 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17