Nephrotoxicity of Amphotericin B

Abstract

Article1 August 1964Nephrotoxicity of Amphotericin BEarly and Late Effects in 81 PatientsWILLIAM T. BUTLER, M.D., JOHN E. BENNETT, M.D., DAVID W. ALLING, M.D., PH.D., PAUL T. WERTLAKE, M.D., JOHN P. UTZ, M.D., GEORGE J. HILL II, M.D.WILLIAM T. BUTLER, M.D., JOHN E. BENNETT, M.D., DAVID W. ALLING, M.D., PH.D., PAUL T. WERTLAKE, M.D., JOHN P. UTZ, M.D., GEORGE J. HILL II, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-2-175 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmphotericin B is the only available drug effective in preventing death from a number of systemic fungal infections. As a result, the drug is widely used despite toxic properties that in other circumstances would render it unacceptable. Important among these toxic effects are impairment of renal function and damage to renal structure.It has been reported that azotemia, decreased renal concentrating power, and decreased phenolsulfonphthalein excretion occur in about three fourths of the patients during the course of administration of amphotericin B (1-7). The significance of the nephrotoxicity of amphotericin B is emphasized by the fact that the daily dose...References1. WINN WA: Seminar on mycotic infections. The use of amphotericin B in the treatment of coccidioidal disease. Amer. J. Med. 27: 617, 1959. CrossrefMedlineGoogle Scholar2. ABERNATHYJANSEN RSGT: Therapy with amphotericin B in North American blastomycosis. Ann. Intern. Med. 53: 1196, 1960. LinkGoogle Scholar3. BEARDRICHERTTAYLOR HWJHRR: The treatment of deep mycotic infections with amphotericin B, with particular emphasis on drug toxicity. Amer. Rev. Resp. Dis. 81: 43, 1960. CrossrefMedlineGoogle Scholar4. 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We renew our thanks to Professor Geddes for generous help with planning and presentation.Antibiotic NephrotoxicityChemotherapy of the Systemic MycosesSODIUM DEPLETION ENHANCES NEPHROTOXICITY OF AMPHOTERICIN BVANCOMYCIN INDUCED NEUTROPENIAWhether or not to Administer Amphotericin to an Immunosuppressed Patient with Hematologic Malignancy and Undiagnosed FevertCandida infection in surgical patientsSTRUCTURE SIDE-EFFECT SORTING OF DRUGS.A Review of Complications of Amphotericin-B Therapy: Recommendations for Prevention and ManagementStrategies in the Treatment of Systemic Fungal InfectionsDrug-Associated NephropathyDrug-Associated NephropathyLack of effect of amphotericin B on urine-bloodpCO2 gradient in spite of urinary acidification defectPharmacologic Aspects of Regular Dialysis TreatmentDiagnosis and Treatment of Systemic MycosesAdverse reactions to anti-infective agentsErythropoietin Concentration in Amphotericin B-Induced AnemiaExistence of Sporothrix schenckii as a Pulmonary SaprophyteRhinocerebral mucormycosisOcular and orbital phycomycosisThe Nephrotoxicity of Antimicrobial AgentsExperience with amphotericin-B in the treatment of systemic candidiasis in burn patients3 Biological Activity of Polyene AntibioticsHamycin: Separation of toxicity and antifungal activity in miceCan Mannitol Reduce Amphotericin B Nephrotoxicity? Double-Blind Study and Description of a New Vascular Lesion in KidneysPSEUDOMEMBRANOUS COLITIS AFTER AMOXYCILLINANTAGONISM BETWEEN MICONAZOLE AND AMPHOTERICIN BSystemic candidiasis and endophthalmitis in neurosurgical patientsCombined Flucytosine — Amphotericin B Treatment of CryptococcosisMucocutaneous leishmaniasis: a review of clinical aspectsDiagnosis and treatment of cutaneous fungus diseasesThe surgical treatment of pulmonary coccidioidomycosisCriptococose do sistema nervoso central: experiência atual do Serviço de Neurologia da Escola Paulista de MedicinaUntoward Effects of Antimicrobial Agents on Major Organ SystemsChemotherapy of Systemic MycosesCryptococcosis and 5-FluorocytosineOn the anatomy of amphotericin B-cholesterol pores in lipid bilayer membranesAmphotericin B Methyl Ester Hydrochloride and Amphotericin B: Comparative Acute ToxicityRhinocerebral phycomycosis (mucorymycosis)Mucormycosis-Changing StatusNephrotoxicity of amphotericin B, with emphasis on changes in tubular functionProblem ClinicSurvival of candida septicaemia treated with amphotericin BProgressive Disseminated Histoplasmosis A Prospective Study of 26 PatientsJAMES W. SMITH, M.D., JOHN P. UTZ, M.D., F.A.C.P.5-Fluorocytosine in the Treatment of Cryptococcal and Candida MycosesROBERT J. FASS, M.D., ROBERT L. PERKINS, M.D., F.A.C.P.HistoplasmosisCryptococcosisHistoplasmosisCryptococcosisRENAL CANDIDIASIS: A Cause of AnuriaThe Treatment of Blastomycosis with Amphotericin BInvasive fungal infections in children: advances and perspectivesAmphotericin B Toxicity A Follow-up Report of 53 PatientsRAYMOND P. MILLER, M.D., JOSEPH H. BATES, M.D., F.A.C.P.Amphotericin B therapy in childrenSuccessful Treatment of Chronic Esophageal Moniliasis with a Viscous Suspension of NystatinHistoplasmosisDie HistoplasmoseNephrotoxic effects of amphotericin B, including renal tubular acidosisCryptococcosis: Current statusResidua from Systemic Candidiasis Treated with AmphotericinTreatment of disseminated mycotic infectionsAmphotericin b Therapy in the Treatment of Presumed Histoplasma ChorioretinitisAntifungal AntibioticsRenal Tubular Acidosis Due to Amphotericin BAlternate-Day Amphotericin B Therapy in the Treatment of Rhinocerebral Phycomycosis (Mucormycosis)DENNIS J. BATTOCK, M.D., HENRY GRAUSZ, M.D., MARTIN BOBROWSKY, M.D., MAXWELL L. LITTMAN, M.D., PH.D.The Significance of CandidemiaCHARLES A. ELLIS, M.D., MARTIN L. SPIVACK, M.D., PH.D.A to of in Patients with Renal A of and M.D., Phycomycosis in with Report of and a Review of Clinical and Experience with Amphotericin B M.D., M.D., A. with an oral Infections of to and the Amphotericin N. M.D., August August by The American of