Interspecific Character of the Müllerian-Inhibiting Substance: Action of the Human Fetal Testis, Ovary and Adrenal on the Fetal Rat Müllerian Duct in Organ Culture

Abstract

Reproductive tracts of 14½-day-old fetal rats were explanted without gonads and placed in organ culture with human testes, ovaries or adrenals from fetuses obtained in the first half of pregnancy. Fetal testicular tissue, irrespective of its age, inhibited the rat müllerian ducts; ovarian and adrenal tissue did not. The significance of these findings is discussed.