Diffusional kurtosis imaging reveals a distinctive pattern of microstructural alternations in idiopathic generalized epilepsy

Abstract

Even though IGE is traditionally considered a 'non-lesional' form of epilepsy, our results demonstrated pervasive thalamo-cortical WM microstructural abnormalities. Particularly, WM abnormalities shown by MK further extended into cortical-cortical projections. This suggests that the extent of microstructural abnormalities in thalamo-cortical projections in IGE may be better assessed through the diffusion metrics provided by DKI.