Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

Grzegorz Grynkiewicz, Martin Poenie, Roger Y. Tsien · Journal of Biological Chemistry · 1985 · 21.7K citations · Full text

Natural Sciences, Biochemistry, Chemistry +17

Acid pH in tumors and its potential for therapeutic exploitation.

Ian F. Tannock, Daniela Rotin · PubMed · 1989 · 1.6K citations

Medicine, Oncology, Pharmacology +16

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

Min Wu, Andy Neilson, Amy L. Swift et al. · American Journal of Physiology-Cell Physiology · 2006 · 920 citations

Life Sciences, Cancer Biology, Oncology +17

Brain and Other Central Nervous System Cancers: Recent Trends in Incidence and Mortality

Jack Legler, Lynn A. G. Ries, Malcolm A. Smith et al. · JNCI Journal of the National Cancer Institute · 1999 · 465 citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

The Relationship between Free and Total Calcium Concentrations in the Matrix of Liver and Brain Mitochondria

Susan Chalmers, David G. Nicholls · Journal of Biological Chemistry · 2003 · 388 citations · Full text

Life Sciences, Physiology, Bioenergetics +11