British Journal of Pharmacology · 1982 · 23 citations · 27 references
MedicinePharmacologyPhysiologyBiochemical PharmacologyMolecular PharmacologyPharmacodynamicsDigestive PhysiologyGastrointestinal FunctionGastrointestinal PathophysiologyGastrointestinal PharmacologyGastrointestinal PhysiologyHormone SecretionCyclic Adenosine Monophosphate PathwayCyclic Adenosine Monophosphate SignalingGastric Ph RegulationGastric SecretionGastric Secretory PhysiologyGastrin SecretionHistamine-mediated SecretionMammalian Gastric Physiology
1 A rat isolated gastric mucosal preparation was used to monitor histamine output and acid secretion during stimulation by different secretagogues. 2 In non-stimulated preparations, spontaneous histamine output decreased over 450 min. 3 Stimulation of secretion with 4 (5)-methylhistamine or dibutyryl cyclic adenosine 3'5'-monophosphate (db cyclic AMP) and theophylline did not influence histamine output. 4 Pentagastrin, gastrin and methacholine increased both acid secretion and histamine output. Pentagastrin and gastrin mobilized six times more histamine and relation to acid secretion than did methacholine. 5 Spontaneous histamine output and secretagogue-induced increases were unaffected by changes in external Ca2+ (0.0 to 7.2 mM) or Mg2+ (1.2 to 4.8 mM). 6 These results support the hypothesis that mucosal histamine plays a more important role in the action of gastrin than of cholinomimetics on the parietal cell.
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Definition and Antagonism of Histamine H2-receptors
J. W. Black, W. A. M. Duncan, C. J. DURANT et al. · Nature · 1972 · 2.3K citations