Magnetic Resonance in Medicine · 1989 · 226 citations · 15 references
MedicineBiomedical SciencesRadiologyBiomedical ImagingDiagnostic ImagingDiagnostic RadiologyDiffusion ImagingMagnetic Resonance ImagingMagnetic Resonance Imaging PhysicsMedical ImagingMedical Imaging PhysicsPerfusion ImagingData Acquisition ParametersDiffusion CoefficientsDiffusion MeasurementsImage Acquisition ParametersIntravoxel Incoherent Motion ImagingMagnetic Field GradientsMolecular DiffusionResidual Effects
The study theoretically analyzes how diffusion and perfusion affect steady‑state free‑precession (SSFP) imaging sequences sensitized to intravoxel incoherent motions, with phantom validation. The authors examine residual T1 and T2 contributions and the influence of sequence parameters—repetition time, flip angle, and gradient pulses—on diffusion measurements, supported by phantom experiments. They demonstrate that SSFP sequences can rapidly image diffusion and perfusion, and that diffusion coefficients can be directly measured when sufficiently large diffusion‑gradient pulses are applied. © 1989 Academic Press, Inc.
Abstract A theoretical analysis of the effects of diffusion and perfusion in steady‐state f ree p recession (SSFP) imaging sequences sensitized to intravoxel incoherent motions by magnetic field gradients is presented and supported by phantom studies. The capability of such sequences to image diffusion and perfusion quickly was recently demonstrated. The possible residual effects of T 1 and T 2 in diffusion measurements are evaluated, as are the effects of the sequence design and the acquisition parameters (repetition time, flip angle, gradient pulses). It is shown theoretically and confirmed by experiments on phantoms that diffusion coefficients can be directly measured from SSFP images when large enough diffusion gradient pulses are used. © 1989 Academic Press, Inc.
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E. L. Hahn · Physical Review · 1950 · 4.9K citations
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