“Paradoxical” analgesia induced by naloxone and naltrexone

Endogenous opioid peptides: multiple agonists and receptors

John A.H. Lord, Angela A. Waterfield, John Hughes et al. · Nature · 1977 · 2.5K citations

Medicine, Endogenous Opioid Peptides, Neuropharmacology +2

Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist

Huda Akil, David J. Mayer, John C. Liebeskind · Science · 1976 · 669 citations

Pain Medicine, Analgesia, Narcotic Antagonist +21

Morphine Analgesic Tolerance: Its Situation Specificity Supports a Pavlovian Conditioning Model

Shepard Siegel · Science · 1976 · 320 citations

Opioid Epidemic, Pain Therapy, Pain Medicine +26

Dose-dependent reductions by naloxone of analgesia induced by cold-water stress

Richard J. Bodnar, Dennis D. Kelly, Angela Spiaggia et al. · Pharmacology Biochemistry and Behavior · 1978 · 313 citations

Health Sciences, Pain Medicine, Medicine +13

Neurochemical and functional correlates of naltrexone-induced opiate receptor up-regulation.

Ann Tempel, Eliot L. Gardner, R. Suzanne Zukin · Journal of Pharmacology and Experimental Therapeutics · 1985 · 204 citations