JAMA · 1985 · 114 citations · 22 references
A three-year epidemic of legionnaires' disease in a hospital was dramatically curtailed following hyperchlorination of the potable water supply. The hypothesis that potable water was the source for the outbreak was further supported by isolation of Legionella pneumophila (the agent of legionnaires' disease) from the hospital water supply, observation that a sudden upsurge had occurred in the number of cases following a peculiar manipulation of the hospital water system, and documentation of a 30-fold increase in concentration of organisms in the water when this manipulation was artificially recreated. Thus, potable water may be an important source of epidemic legionnaires' disease and continuous hyperchlorination a method of control.
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David W. Fraser, Theodore R. Tsai, Walter A. Orenstein et al. · New England Journal of Medicine · 1977 · 1.7K citations
Pittsburgh Pneumonia Agent: Direct Isolation from Human Lung Tissue
A. William Pasculle, J C Feeley, R. J. Gibson et al. · The Journal of Infectious Diseases · 1980 · 292 citations
LEGIONELLACEAE IN THE HOSPITAL WATER-SUPPLY
Michele Best, Janet E. Stout, RobertR. Muder et al. · The Lancet · 1983 · 257 citations
Healthcare-associated Infection, Microbiology, Infection Control +3