Concepedia

CuSO<sub>4</sub>–<scp>d</scp>-glucose, an inexpensive and eco-efficient catalytic system: direct access to diverse quinolines through modified Friedländer approach involving S<sub>N</sub>Ar/reduction/annulation cascade in one pot

Namrata Anand, Tanmoy Chanda, Suvajit Koley, Sushobhan Chowdhury, Maya Shankar Singh

RSC Advances · 2014 · 41 citations · 51 references

DOI

Concepts

Abstract

A one-pot, efficient approach to quinoline synthesis, directly from 2-bromoaromatic aldehydes/ketones in a H<sub>2</sub>O–EtOH mixture involving a sequence of S<sub>N</sub>Ar/reduction/annulation cascade using CuSO<sub>4</sub>-<sc>d</sc>-glucose, is devised.

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