Human Papillomavirus Associated With Keratoacanthoma

Abstract

<h3>To the Editor.—</h3> At least 58 types of human papillomaviruses (HPVs) have been identified to date, and they are associated with a variety of cutaneous diseases. Human papillomavirus has long been known to cause common warts and condylomata accuminata, and certain HPV types have been linked to bowenoid papulosis, genital Bowen's disease, genital squamous cell carcinoma, and epidermodysplasia verruciformis. More recently, there has been some association of HPV with nongenital Bowen's disease and nongenital squamous cell carcinoma. There have been isolated reports of the detection of HPV DNA in basal cell carcinoma, malignant melanoma, solar keratosis, and hairy leukoplakia, but the significance of these findings is uncertain. Several European reports have described the detection of HPV in keratoacanthoma (KA),^1-3but, to our knowledge, there have been no reports from the United States until now. We report the detection of HPV in eight keratoacanthomas using DNA hybridization techniques. <h3>Materials and</h3>