Interplay of glucose-stimulated Ca2+ sequestration and acetylcholine-induced Ca2+ release at the endoplasmic reticulum in rat pancreatic β-cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

Grzegorz Grynkiewicz, Martin Poenie, Roger Y. Tsien · Journal of Biological Chemistry · 1985 · 21.7K citations · Full text

Natural Sciences, Biochemistry, Chemistry +17

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

Ole Thastrup, Peter J. Cullen, Bjørn K. Drøbak et al. · Proceedings of the National Academy of Sciences · 1990 · 3.3K citations

Life Sciences, Cell Biology, Pharmacology +15

Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

Jonathan Lytton, Marisa M. Westlin, Michael R. Hanley · Journal of Biological Chemistry · 1991 · 1.3K citations · Full text

Life Sciences, Biochemistry, Cell Biology +15

Cyclic ADP-Ribose in Insulin Secretion from Pancreatic βCells

Shin Takasawa, Koji Nata, Hideto Yonekura et al. · Science · 1993 · 443 citations

Life Sciences, Biochemistry, Cell Biology +17

Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues

Olivier Blondel, Junji Takeda, Hans Janssen et al. · Journal of Biological Chemistry · 1993 · 317 citations · Full text

Life Sciences, Pharmacology, Physiology +17