Chlorpromazine induces apoptosis in activated human lymphoblasts: A mechanism supporting the induction of drug‐induced lupus erythematosus?

Abstract

These data suggest that chlorpromazine mediates apoptosis in human lymphoblasts through specific activation of intracellular proapoptotic signaling cascades. This mechanism might lead to an unsynchronized inflow of apoptotic break-down products and thereby to the induction of (auto)immunity against nuclear components.