Science · 1996 · 408 citations · 18 references
Life SciencesPlant BiologyPlant SciencesPlant BiochemistryPlant Molecular BiologySignal TransductionHormonal Regulation Of DevelopmentPlant EnzymesPlant Hormone PhysiologyPlant Hormone SignalingPlant HormonesSignal Transduction In PlantsAbscisic Acid Response GenesAbscisic Acid Signaling GeneticsDevelopmental Regulation By Abscisic AcidHormone Signaling In Stress ResponsesMembrane Protein LocalizationPlant Hormone Signaling In StressSensitivitySignal Transduction In Proteins
The hormone abscisic acid (ABA) modulates a variety of developmental processes and responses to environmental stress in higher plants. A collection of mutations, designated era, in Arabidopsis thaliana that confer an enhanced response to exogenous ABA includes mutations in the Era1 gene, which encodes the beta subunit of a protein farnesyl transferase. In yeast and mammalian systems, farnesyl transferases modify several signal transduction proteins for membrane localization. The era1 mutants suggest that a negative regulator of ABA sensitivity must be acted on by a farnesyl transferase to function.
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