Angiotensin-Converting Enzyme-2 Overexpression Improves Left Ventricular Remodeling and Function in a Rat Model of Diabetic Cardiomyopathy

Angiotensin-converting enzyme 2 is an essential regulator of heart function

Michael A. Crackower, Renu Sarao, Gavin Y. Oudit et al. · Nature · 2002 · 1.8K citations

Life Sciences, Cardiology, Physiology +10

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

Norifumi Takeda, Ichiro Manabe, Yuichi Uchino et al. · Journal of Clinical Investigation · 2009 · 392 citations · Full text

Life Sciences, Cardiology, Physiology +11

Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis

Vivek Singh, Bao T. Le, Renu Khode et al. · Diabetes · 2008 · 332 citations · Full text

Medicine, Cardiology, Pharmacology +15

Contributions of Inflammation and Cardiac Matrix Metalloproteinase Activity to Cardiac Failure in Diabetic Cardiomyopathy

Dirk Westermann, Susanne Rutschow, Sebastian Jäger et al. · Diabetes · 2007 · 268 citations · Full text

Medicine, Cardiology, Pharmacology +17

Genetic <i>Ace2</i> Deficiency Accentuates Vascular Inflammation and Atherosclerosis in the <i>ApoE</i> Knockout Mouse

Merlin C. Thomas, R. J. Pickering, Despina Tsorotes et al. · Circulation Research · 2010 · 232 citations

Veterinary Medicine, Cell Biology, Pathobiology +16