Survey of Anesthesiology · 1981 · 25 citations · 0 references
MedicineMedicinal ChemistryNeurologyNeuromuscular DisordersNeuromuscular BlockadeNeuromuscular Blocking AgentsNeuromuscular FunctionNeuromuscular JunctionNeuromuscular PhysiologySteroid PharmacologyNeuromuscular Blocking Agent PharmacodynamicsSensitivity To Neuromuscular Blocking AgentsSteroid Neuromuscular Blockers
The action of a new steroid compound, pancuronium bromide (NA97) on the myoneural junction in man has been studied. The drug was shown to produce myoneural blockade which was reversible with neostigmine. A 2-mg dose of pancuronium bromide produced a degree of blockade similar in intensity and duration to that of 10–15 mg of tubocurarine. Electromyography showed a rapid fall-off in tetanus followed by post-tetanic facilitation. These facts would point to the blockade being of the non-depolarizing or curariform type. On intravenous injection of the drug there were no changes in pulse rate or systolic blood pressure. Further investigation of the effects of pancuronium bromide in man would seem to be indicated.