Allergy · 1994 · 75 citations · 10 references
PharmacyPharmacologyPharmacotherapyDosage Form DesignPulmonologyRespiratory PharmacotherapyBronchodilator TherapyCombination Inhaler TherapyInhalation Dosage FormsInhalation TherapyMetered-dose InhalersRespiratory MedicineInhaled Corticosteroid AdministrationInhaled Corticosteroid EffectsMetered-dose Inhaler UsePressurized Inhaler TechniquePressurized Metered Dose InhalersSpacer DesignSpacer SystemsSpacer Technology
Local side-effects, such as hoarseness and oropharyngeal candidiasis, are often seen during treatment of patients with inhaled corticosteroids (ICS). We investigated whether changing from pressurized metered-dose inhalers (pMDI) to Turbuhaler influenced the type and frequency of local side-effects. Local side-effects were recorded for a 2-year period in which 154 patients used ICS pMDI with a spacer device. They were followed for an equally long period of time (26.2 +/- 5.7 months) while using Turbuhaler, as were 90 patients who received Turbuhaler as their first ICS preparation. After inhalation, all patients rinsed out their mouths with water. In experienced pMDI-users, the frequency of local side-effects decreased from 21% to 6%. The reduction was due to a lower incidence of hoarseness. Candidiasis or hoarseness was not seen in patients given Turbuhaler as their first ICS device. Our fear of an increased incidence of local side-effects when giving ICS in Turbuhaler was unwarranted.
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Deposition of pressurised aerosols in the human respiratory tract.
Stephen P. Newman, D Pavia, Folke Morén et al. · Thorax · 1981 · 378 citations · Full text
Improvement of pressurised aerosol deposition with Nebuhaler spacer device.
Stanton Newman, Ann Millar, Timothy Lennard-Jones et al. · Thorax · 1984 · 258 citations · Full text