Leukocyte and Platelet Depletion Protects the Liver from Damage Induced by Cholestasis and Ischemia–Reperfusion in the Dog

Abstract

Depletion of leukocytes and platelets thus appears to protect liver function from cholestasis and ischemia-reperfusion injury by reducing peroxidation of lipids composing the cell membrane and the rate of thromboxane A2 prostaglandin I2, which predicts cellular damage, and by increasing the levels of alpha-tocopherol and glutathione, believed to be free radical scavengers.