Direct and Waste‐Free Amidations and Cycloadditions by Organocatalytic Activation of Carboxylic Acids at Room Temperature

Abstract

Taming carboxylic acids: ortho-Iodo- and ortho-bromophenylboronic acids are exceptional organocatalysts in atom-economical amidations between free carboxylic acids and amines, including functionalized ones, and can also provide LUMO-lowering activation in [4+2] cycloadditions of α,β-unsaturated carboxylic acids.