Accumulation of mitochondrial DNA deletions in the malignant prostate of patients of different ages

Aging: A Theory Based on Free Radical and Radiation Chemistry

Denham Harman · Journal of Gerontology · 1956 · 8.5K citations

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Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

César G. Fraga, Mark K. Shigenaga, J W Park et al. · Proceedings of the National Academy of Sciences · 1990 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +16

Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

Makiko Fliss, Henning Usadel, Otávia L. Caballero et al. · Science · 2000 · 823 citations

Medicine, Molecular Biology, Oncology +12

Hydrogen peroxide release by mitochondria increases during aging

Rajindar S. Sohal, Barbara H. Sohal · Mechanisms of Ageing and Development · 1991 · 295 citations

Life Sciences, Biochemistry, Physiology +14

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

Simon Melov, John M. Shoffner, A. Kaufman et al. · Nucleic Acids Research · 1995 · 273 citations · Full text

Life Sciences, Genetics, Molecular Biology +14