An efficient synthesis of 3,4-dihydropyrimidin-2-ones catalyzed by NH2SO3H under ultrasound irradiation

100 years of the biginelli dihydropyrimidine synthesis

C. Oliver Kappe · Tetrahedron · 1993 · 1.2K citations

Bioorganic Chemistry, Biochemistry, Natural Sciences +3

Lanthanide Triflate Catalyzed Biginelli Reaction. One-Pot Synthesis of Dihydropyrimidinones under Solvent-Free Conditions

Yun Ma, Changtao Qian, Limin Wang et al. · The Journal of Organic Chemistry · 2000 · 515 citations

Combinatorial Chemistry, Chemical Engineering, Engineering +10

Unprecedented Catalytic Three Component One-Pot Condensation Reaction:  An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones

Essa Hu, Daniel R. Sidler, Ulf‐H. Dolling · The Journal of Organic Chemistry · 1998 · 498 citations

Chemical Engineering, Cross-coupling Reaction, Engineering +11

Indium(III) Chloride-Catalyzed One-Pot Synthesis of Dihydropyrimidinones by a Three-Component Coupling of 1,3-Dicarbonyl Compounds, Aldehydes, and Urea: An Improved Procedure for the Biginelli Reaction

Brindaban C. Ranu, Alakananda Hajra, Umasish Jana · The Journal of Organic Chemistry · 2000 · 472 citations

Chemical Engineering, Diversity Oriented Synthesis, 1,3-Dicarbonyl Compounds +11

Conformational analysis of 4-aryl-dihydropyrimidine calcium channel modulators. A comparison of ab initio, semiempirical and X-ray crystallographic studies

C. Oliver Kappe, Walter M. F. Fabian, M.A. Semones · Tetrahedron · 1997 · 402 citations

X-ray Crystallography, X-ray Crystallographic Studies, Crystal Structure +7