TRANSFORMING GROWTH FACTOR-?? INHIBITS LYMPHOKINE ACTIVATED KILLER CYTOTOXICITY OF BONE MARROW CELLS

Abstract

High-dose TBI-induced, host-derived splenic TGF-beta may inhibit generation of LAK cells from subsequently transplanted donor BM cells, suppressing their capacity to generate cytotoxicity upon injection of leukemia cells. The cytokine profile, induced by irradiation in host hematopoietic organs, can significantly modify posttransplant immunological processes such as the GVL effect and graft-versus-host disease (GVHD).