Concepedia

Role of Hypoxia during Normal Retinal Vessel Development and in Experimental Retinopathy of Prematurity

Wei Zhang, Yasuki Ito, Emily Berlin, Robin Roberts, Bruce A. Berkowitz

Investigative Ophthalmology & Visual Science · 2003 · 68 citations · 20 references

DOI

Abstract

(19)F MRS of a perfluorocarbon droplet provides an accurate measure of preretinal vitreous oxygen tension in rats. These data support an important role of physiologic hypoxia in normal retinal circulatory development and raises the possibility that, in experimental ROP, retinal hypoxia is a necessary but not sufficient condition for the development of retinal NV.

References

20

Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia

Jennifer D. Stone, Ahuva Itin, Tamir Alon et al. · Journal of Neuroscience · 1995 · 1K citations · Full text

, , +14

Exposure to Alternating Hypoxia and Hyperoxia Causes Severe Proliferative Retinopathy in the Newborn Rat

John S. Penn, Mark M Henry, Barbara L. Tolman · Pediatric Research · 1994 · 268 citations · Full text

, , +9

The effect of oxygen on vasoformative cell division. Evidence that 'physiological hypoxia' is the stimulus for normal retinal vasculogenesis.

Tailoi Chan‐Ling, B. Gock, Jonathan Stone · PubMed · 1995 · 243 citations

Intraretinal oxygen levels before and after photoreceptor loss in the RCS rat.

Dao‐Yi Yu, Stephen J. Cringle, E N Su et al. · PubMed · 2000 · 160 citations

Rapid tissue oxygen tension mapping using <sup>19</sup>F inversion‐recovery echo‐planar imaging of P erfluoro‐15 ‐crown‐5‐ether

Bernard J. Dardzinski, Christopher H. Sotak · Magnetic Resonance in Medicine · 1994 · 150 citations