Myocardial Protection by Preconditioning of Heart With Losartan, an Angiotensin II Type 1-Receptor Blocker : Implication of Bradykinin-Dependent and Bradykinin-Independent Mechanisms - Concepedia

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Myocardial Protection by Preconditioning of Heart With Losartan, an Angiotensin II Type 1-Receptor Blocker : Implication of Bradykinin-Dependent and Bradykinin-Independent Mechanisms

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References

2000

Year

Masa H. Sato, Richard M. Engelman, Hajime Otani, Nilanjana Maulik, J. A. Rousou, Joseph E. Flack, David W. Deaton, Durga Das

Abstract

The results document that losartan reduced whereas HOE 140 increased myocardial ischemia/reperfusion injury by blocking AT(1) and bradykinin B(2) receptors, respectively, suggesting a role of the bradykinin B(2) receptor in PC. Losartan provided cardioprotection through both bradykinin-dependent and bradykinin-independent mechanisms.