Concepedia

1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)

Dirk A. Heerding, George Chan, Walter E. DeWolf, Andrew Fosberry, Cheryl A. Janson, Deborah D. Jaworski, Edward C. McManus, William H. Miller, Terrance Moore, David Payne,

Bioorganic & Medicinal Chemistry Letters · 2001 · 124 citations · 15 references

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Concepts

Inhibitory ActivityMedicinal ChemistryAntimicrobial Drug DiscoveryBiochemistryMedicineNatural Sciences1,4-Disubstituted ImidazolesAntibacterial AgentAntimicrobial ChemotherapyPotential Antibacterial AgentsAntimicrobial CompoundChemical BiologyPharmacologyPharmaceutical ChemistryAntimicrobial ResistanceDrug Discovery

References

15

The animal fatty acid synthase: one gene, one polypeptide, seven enzymes

The FASEB Journal · 1994 · 596 citations

Bioorganic Chemistry, Engineering, Biosynthesis +18

Mechanism of Triclosan Inhibition of Bacterial Fatty Acid Synthesis

Richard J. Heath, John R. Rubin, Debra R. Holland et al. · Journal of Biological Chemistry · 1999 · 542 citations · Full text

Enoyl-Acyl Carrier Protein Reductase (fabI) Plays a Determinant Role in Completing Cycles of Fatty Acid Elongation in Escherichia coli

Richard J. Heath, Charles O. Rock · Journal of Biological Chemistry · 1995 · 366 citations · Full text

Biosynthesis, Cellular Enzymology, Biochemistry +14

A triclosan-resistant bacterial enzyme

Richard J. Heath, Charles O. Rock · Nature · 2000 · 285 citations

Antimicrobial Resistance Gene, Microbiology, Antimicrobial Compound +5

A manual method for applying the Hansch approach to drug design

John G. Topliss · Journal of Medicinal Chemistry · 1977 · 216 citations · Full text