Concepedia

Pushing the Limits for Thiol−Ene and CuAAC Reactions: Synthesis of a 6th Generation Dendrimer in a Single Day

Per Antoni, Maxwell J. Robb, Luis M. Campos, María I. Montañez, Anders Hult, Eva Malmström, Michael Malkoch, Craig J. Hawker

Macromolecules · 2010 · 170 citations · 39 references

DOI

Abstract

Dendrimer synthesis should not be tedious and time-consuming. By utilizing an AB2−CD2 approach and having orthogonal, “clickable” groups on each monomer, the time for dendrimer assembly can be drastically reduced. This was shown by preparation of a sixth generation dendrimer from starting monomer units in a single day.

References

39

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.4K citations

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Peptidotriazoles on Solid Phase:  [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides

Christian W. Tornøe, Caspar Christensen, Morten Meldal · The Journal of Organic Chemistry · 2002 · 8.4K citations

, , +15

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Craig J. Hawker, Jean M. J. Fréchet · Journal of the American Chemical Society · 1990 · 2.4K citations

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‘Click’ Chemistry in Polymer and Materials Science

Wolfgang H. Binder, Robert Sachsenhofer · Macromolecular Rapid Communications · 2007 · 1.5K citations

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"Cascade"- and "Nonskid-Chain-like" Syntheses of Molecular Cavity Topologies

E. BUHLEIER, Winfried Wehner, Fritz Vögtle · Synthesis · 1978 · 1.3K citations

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