Applications of a 7-day Caco-2 cell model in drug discovery and development

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

Ismael J. Hidalgo, Thomas J. Raub, Ronald T. Borchardt · Gastroenterology · 1989 · 2.2K citations

Medicine, Gastroenterology, Pathology +10

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Per Artursson, Johan Karlsson · Biochemical and Biophysical Research Communications · 1991 · 1.8K citations

Health Sciences, Medicine, Physiology +9

Physicochemical High Throughput Screening:  Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

Manfred Kansy, Frank Senner, Klaus Gubernator · Journal of Medicinal Chemistry · 1998 · 1.3K citations

Pharmaceutical Science, Engineering, Quantitative Pharmacology +21

MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening

Jennifer D. Irvine, Lori H. Takahashi, Karen Lockhart et al. · Journal of Pharmaceutical Sciences · 1999 · 956 citations

Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells

Shinji Yamashita, Tomoyuki Furubayashi, Makoto Kataoka et al. · European Journal of Pharmaceutical Sciences · 2000 · 554 citations

Caco-2 Cells, Physiologically-based Pharmacokinetic Modeling, Medicine +9