The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Jordi Barretina, Giordano Caponigro, Nicolas Stransky, +57

Nature

Tumor BiologyPredictive ModellingDrug TargetOncologyEngineering +10

Dystrophin: The protein product of the duchenne muscular dystrophy locus

Eric P. Hoffman, Robert H. Brown, Louis M. Kunkel

Cell

Protein FunctionBiochemistrySkeletal MuscleProtein FoldingNatural Sciences +6

Gain-of-Function Mutations of c- <i>kit</i> in Human Gastrointestinal Stromal Tumors

Seiichi Hirota, Koji Isozaki, Y Moriyama, +12

Science

<i>PDGFRA</i> Activating Mutations in Gastrointestinal Stromal Tumors

Michael C. Heinrich, Christopher L. Corless, Anette Duensing, +10

Science

Membrane organization of the dystrophin-glycoprotein complex

James M. Ervasti, Kevin P. Campbell

Cell

BiochemistryNatural SciencesMembrane BiologyIntracellular TraffickingCellular Biochemistry +4

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

Sebahattin Çirak, Virginia Arechavala‐Gomeza, Michela Guglieri, +17

The Lancet

Exon SkippingUrologyDuchenne Muscular DystrophyPhase 2Medicine +2

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

Jordi Barretina, Barry S. Taylor, Shantanu Banerji, +42

Nature Genetics

Tumor HeterogeneityMedicinePathologyCancer GenomicsSubtype-specific Genomic Alterations +4

Characterization of a newly derived human sarcoma cell line (HT-1080)

Suraiya Rasheed, Walter A. Nelson‐Rees, Eva M. Toth, +2

Cancer

ImmunologyPathologyCell ProliferationCancer BiologyTumor Biology +14

Dystrophin‐deficient <i>mdx</i> mice display a reduced life span and are susceptible to spontaneous rhabdomyosarcoma

Jeffrey S. Chamberlain, Joseph M. Metzger, Morayma Reyes, +2

The FASEB Journal

The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas

Eva Hernando, Elizabeth Charytonowicz, Mária Dudás, +9

Nature Medicine

Akt-mtor PathwayMedicineCritical RolePathologyTumor Suppressor +3