Concepedia

EMMPRIN and MMP-1 in Keratoconus

Hannu P. S. Seppälä, Marko Määttã, Mikko Rautia, Zygmunt Mackiewicz, Ilpo S. Tuisku, Timo Tervo, Yrjö T. Konttinen

Cornea · 2006 · 69 citations · 27 references

DOI

Abstract

Both EMMPRIN and MMP-1 are upregulated in keratoconus, but MMP-1 may not be the only tissue destructive MMP upregulated by EMMPRIN as only EMMPRIN expression correlated topologically very well with corneal damage.

References

27

The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily.

Chitra Biswas, Y Zhang, Rosana DeCastro et al. · PubMed · 1995 · 724 citations

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Epithelial Injury Induces Keratocyte Apoptosis: Hypothesized Role for the Interleukin-1 System in the Modulation of Corneal Tissue Organization and Wound Healing

Steven E. Wilson, Yu-Guang He, Jian Weng et al. · Experimental Eye Research · 1996 · 587 citations

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Matrix Metalloproteinase-8 Is Expressed in Rheumatoid Synovial Fibroblasts and Endothelial Cells

Roeland Hanemaaijer, Timo Sorsa, Yrjö T. Konttinen et al. · Journal of Biological Chemistry · 1997 · 488 citations · Full text

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Collagen fibril orientation in the human corneal stroma and its implication in keratoconus.

Albert Daxer, Peter Fratzl · PubMed · 1997 · 324 citations

Abnormalities of the Extracellular Matrix in Keratoconus Corneas

M. Cristina Kenney, Anthony B. Nesburn, Robert E. Burgeson et al. · Cornea · 1997 · 190 citations