Correlation of pharmacokinetics with the antitumor activity of Cetuximab in nude mice bearing the GEO human colon carcinoma xenograft

Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.

Emil J. Freireich, E. A. Gehan, David P. Rall et al. · PubMed · 1966 · 1.4K citations

Comparative Toxicology, Quantitative Comparison, Medicine +10

Phase I and Pharmacologic Study of OSI-774, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced Solid Malignancies

Manuel Hidalgo, Lillian L. Siu, John Nemunaitis et al. · Journal of Clinical Oncology · 2001 · 997 citations

Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.

Tomoyuki Kawamoto, Jun Sato, Anh D. Le et al. · Proceedings of the National Academy of Sciences · 1983 · 793 citations · Full text

Epidermal Growth Factor, Immunology, Cell Proliferation +16

Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model.

Neil I. Goldstein, Marie Prewett, Kazys Zuklys et al. · PubMed · 1995 · 791 citations

Immunology, Biological Efficacy, Cell Growth +17

Phase I Studies of Anti–Epidermal Growth Factor Receptor Chimeric Antibody C225 Alone and in Combination With Cisplatin

José Baselga, David G. Pfister, Michael R. Cooper et al. · Journal of Clinical Oncology · 2000 · 743 citations