Current trends in antimalarial chemotherapy

Abstract

This review discusses the commercially available antimalarial drugs that are classified according to their chemical entities and include quinolines, pyrimidines, amidines, guanidines, sulfonamides, sulfones, acridines, antibiotics and sesquiterpene lactones. New anti-malarials reported during 2000 to June 2002 are also classified according to their chemical structures and include trioxanes, tetraoxane derivatives, other peroxides, quinolines and bisquinolines, isoquinolines, pyrimidines, acridine and bisacridine derivatives, bis acyl amino benzophenone, cinnamic acid derivatives, natural products, phenyl β-methoxy acrylates, pyrrolidines, carbolines, imidazoles and tropolones. The complications of malarial chemotherapy are also discussed.