Circulation Research · 1959 · 35 citations · 13 references
Electrolyte DisorderCardiac EffectsCardiovascular PharmacologySignificant Ph ChangeDiastolic FunctionVarious Sympathomimetic AminesElectrolyte DisturbanceExperimental AcidosisIdioventricular RatePublic HealthCardiologyAnimal PhysiologyAnesthesia PracticePharmacologyAnaesthetic AgentCardiovascular DiseasePhysiologyElectrophysiologyCardiovascular PhysiologyAnesthesiaMedicineAnesthesiology
Acidosis was found to diminish the effectiveness of various sympathomimetic amines (isoproterenol, norepinephrine, and epinephrine) in increasing the idioventricular rate in dogs with experimentally induced complete A-V heart block. This diminution was correlated with the degree of acidosis (metabolic and respiratory). Hyperkalemia without significant pH change had no such effect.
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