Thrombin generation in children with sickle cell disease: relationship with age, hemolysis, transcranial <scp>d</scp>oppler velocity, and hydroxyurea treatment

Abstract

Elevated TG in SCD children is mainly related to younger age and to the intensity of hemolysis. There probably a link between TG and cerebral vasculopathy in these patients. Hydroxyurea may have a beneficial effect, which could be related to the duration of treatment.