Gene-Gene-Sex Interaction in Cytokine Gene Polymorphisms Revealed by Serum Interferon Alpha Phenotype in Juvenile Dermatomyositis

Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies

Andrew D. Skol, Laura J. Scott, Gonçalo R. Abecasis et al. · Nature Genetics · 2006 · 1.3K citations

Genome-wide Association Study, Genetics, Computational Genomics +9

Immune Interferon in the Circulation of Patients with Autoimmune Disease

John J. Hooks, Haralampos Μ. Moutsopoulos, Shirley A. Geis et al. · New England Journal of Medicine · 1979 · 917 citations

Immunology, Immunotherapy, Type Ii +17

Activation of the interferon‐α pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease

Kyriakos A. Kirou, Christina Lee, Sandhya George et al. · Arthritis & Rheumatism · 2005 · 686 citations

Three functional variants of IFN regulatory factor 5 ( <i>IRF5</i> ) define risk and protective haplotypes for human lupus

Robert Graham, Chieko Kyogoku, Irina Vlasova-St. Louis et al. · Proceedings of the National Academy of Sciences · 2007 · 454 citations · Full text

Genetics, Immunology, Human Polymorphism +19

High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus

Timothy B. Niewold, Jing Hua, Thomas J A Lehman et al. · Genes and Immunity · 2007 · 420 citations · Full text

Inflammation, Rheumatology, Heritable Risk Factor +11