Estrogen-Dependent Actions of Bone Morphogenetic Protein-7 on Spine Fusion in Rats

Payam Moazzaz, Munish C. Gupta, Mudit M. Gilotra, Mohit N. Gilotra, Sukanta Maitra, Thongchai Theerajunyaporn, James L. Chen, A. Hari Reddi, R. Bruce Martin

Spine · 2005 · 46 citations · 24 references

Abstract

These data suggest that spinal fusion using rhBMP-7 is estrogen-dependent in rats. At the dosages used, rhBMP-7 was unable to overcome the inhibitory effects of estrogen deficiency on spinal fusion.

References

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