Effect of pre-contraction on β-adrenoceptor-mediated relaxation of rat urinary bladder

Abstract

We conclude that β-adrenoceptor agonists can induce rat bladder relaxation against a wide range of contractile stimuli and are more potent and/or effective against non-cholinergic stimuli than against muscarinic agonism. This profile appears desirable for agents intended for the treatment of overactive bladder.

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