Advanced Synthesis & Catalysis · 2006 · 35 citations · 0 references
Natural SciencesChemical EngineeringChemistryCatalysisCombinatorial ChemistryPolymer ChemistryCatalyst DesignPolymer FunctionalizationAllylic SubstitutionAsymmetric CatalysisAsymmetric Catalyst DesignLigand DesignPalladium CatalystsPolystyrene Resin SupportsTether Design
Abstract A library of amphiphlic polystyrene‐poly(ethylene glycol) (PS‐PEG) resin‐supported chiral phosphine ligands was prepared by the split method using porous miniature reactors. A polymeric ( R )‐2‐(diphenylphosphino)binaphthyl (MOP) ligand anchored onto the PS‐PEG resin by an ( S )‐alanine tether unit was identified through the library‐based screening to be an effective chiral ligand for the asymmetric palladium‐catalyzed π‐allylic substitution under heterogeneous aqueous conditions.