SW-163C and E, Novel Antitumor Depsipeptides Produced by Streptomyces sp. I. Taxonomy, Fermentation, Isolation and Biological Activities.

Abstract

Novel depsipeptides, SW-163C and E were isolated from the culture broth of an actinomycete strain. The producing organism, designated as SNA15896, was identified as a member of Streptomyces from its morphological and cultural characteristics. SW-163C and E exhibited potent antitumor activities against various tumor cell lines in vitro and against murine leukemia P388 in vivo. The compounds also showed antimicrobial activities.