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AN AUTORADIOGRAPHIC STUDY ON THE LOCALIZATION OF ANDROGEN IN THE PROSTATE GLAND AND THE SEMINAL VESICLES OF THE MALE RAT
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1970
Year
SpermatogenesisThe Male RatGynecologySignificant LabellingFemale Reproductive FunctionReproductive BiologyPreferential LabellingReproductive EndocrinologyUrogenital RadiologyReproductive MedicinePublic HealthNuclear MedicineRadiologyInfertilityAndrologyRadiological SciencesHormonal ReceptorHistopathologyProstatic DiseaseEndocrinologyDistinct LabellingUrologyMedicineEndocrine ResearchReproductive Hormone
ABSTRACT The distribution of radioactive material in the prostate gland and the seminal vesicles has been studied by autoradiography after intramuscular administration of [1,2- 3 H] testosterone in vivo to adult castrated male rats. Positive autoradiographs were obtained from 7½ min to 8 h after the administration. As early as after 15 min, there appeared to be a selective localization of radioactivity in the epithelial cells, with much of the labelling associated with the nuclei; the stromal labelling was markedly less. This picture was even more significant ½, 1 and 2 h after the injection, when the autoradiographs demonstrated a preferential labelling of the nuclei of the epithelial cells. A distinct labelling of the epithelial cells was also found 8 h after the injection. The same qualitative pattern of distribution of radioactivity was seen in the four prostatic lobes and the seminal vesicles. No significant labelling of the secretions in the glandular lumina was observed.