Angewandte Chemie International Edition · 2000 · 141 citations · 0 references
Natural SciencesChemistryGreen ChemistryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsOrganic SynthesisRadical ReactionsRadical CyclizationRing-forming Reactions
Environmentally benign tin-free radical cyclization reactions allow the preparation of cyclic alcohol derivatives. The isomerizations are very easy to conduct and proceed in high yields for alkoxyamines with weak C−O bonds [Eq. (1); R=Ph, functionalized aryl, heteroaryl, ester, or nitrile group]. As a first application of the new method, the preparation of a complex tetracycle is presented.