New England Journal of Medicine · 2000 · 409 citations · 32 references
Life SciencesGeneticsMolecular GeneticsGenomicsHuman GeneticsMedical GeneticsClinical GenomicsGenetic DisordersGenetic TestingHistory Of GeneticsPredictive Genetic Testing
On both sides of the Atlantic, revolutionary claims have been made about the ultimate impact of genetics on clinical medicine. John Bell at Oxford has asserted that “within the next decade genetic testing will be used widely for predictive testing in healthy people and for diagnosis and management of patients. . . The excitement in the field has shifted to the elucidation of the genetic basis of the common diseases.”1 And in the United States the director of the National Human Genome Research Institute, Francis Collins, has stated that the good that would come from mapping the human genetic . . .
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A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder, Andreas Gnirke, Zenta Tsuchihashi et al. · Nature Genetics · 1996 · 3.7K citations