Indomethacin lengthens the oestrous cycle of the guinea-pig when given orally with oestrogen or when implanted within the uterine lumen

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

J. Bryan Smith, A.L. Willis · Nature New Biology · 1971 · 1.5K citations

Medicine, Pharmacology, Pharmacotherapy +14

Indomethacin and Aspirin abolish Prostaglandin Release from the Spleen

S. H. Ferreira, Salvador Moncada, John R. Vane · Nature New Biology · 1971 · 934 citations

Veterinary Medicine, Pharmacology, Inflammation +5

Ovulation blockade by aspirin or indomethacin - in vivo evidence for a role of prostaglandin in gonadotrophin secretion

Gayle P. Orczyk, Harold R. Behrman · Prostaglandins · 1972 · 310 citations

Medicine, Endocrinology, Pharmacology +16

Aspirin and Indomethacin Prolong Parturition in Rats: Evidence that Prostaglandins Contribute to Expulsion of Foetus

James W. Aiken · Nature · 1972 · 197 citations

Medicine, Obstetrics, Pharmacology +13